COMPARE AND CONTRAST CONFORMAL PHOTON TREATMENT TECHNIQUES AND PROTON TREATMENTS FROM A RADIOBIOLOGICAL PERSPECTIVE.A 30 year old man had an orchidectomy for a seminoma of the testis and is to be treated with radiotherapy to the para-aortic and ipsilateral iliac region.

COMPARE AND CONTRAST CONFORMAL PHOTON TREATMENT TECHNIQUES AND PROTON TREATMENTS FROM A RADIOBIOLOGICAL PERSPECTIVE.A 30 year old man had an orchidectomy for a seminoma of the testis and is to be treated with radiotherapy to the para-aortic and ipsilateral iliac region.
Compare and contrast conformal photon treatment techniques and proton treatmentsfrom a RADIOBIOLOGICAL perspective
1 A 30 year old man had an orchidectomy for a seminoma of the testis and is to betreated with radiotherapy to the para-aortic and ipsilateral iliac region. Inevitably somescattered radiation will occur to the remaining testicle. Assuming that the remainingtesticle receives a total dose of approximately 0.5Gy,discuss the biological consequencesof such a dose. What advice would you give regarding future fertility and hazards toprogeny?2 Compare and contrast conformal photon treatment techniques and proton treatmentsfrom a RADIOBIOLOGICAL perspective.3 A planning error resulted in the delivery of 4 Gy per fraction for a patient being treatedradically for tonsillar cancer. His treatment was stopped after 14 fractions to a dose of54 Gy. His original prescription was for 70 Gy in 35 fractions over 7 weeks. Describethe expected acute and late effects on all the sensitive tissues of relevance for the actualand intended treatment and outline the potential risks in terms of tumour cure ratesarising from this error. (Assume all relevant late reacting tissues have an alpha/beta of 2and acute reacting tissues and tumour a value of 10. Assume re-population begins at16 days into treatment).4 Cell loss is an important kinetic factor which contributes to the dynamic state of tumourgrowth. Describe the various mechanisms by which cell loss occurs, how it is measuredin normal and neoplastic tissues and, in particular, the relevance of cell loss in tumourgrowth pre-irradiation and post-irradiation5 Write short notes on any three of the following:a) Radiation effects on the parotid glandb) Inflammatory Modulators of Radiation Reactionsc) Free Radicalsd) Radiation Pneumonitis arising from Chemoradiotherapy Treatment

 
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