According to the American Diabetes Association (2011), 25.8 million children and adults have been diagnosed with diabetes in the United States. Approximately 2 million more are diagnosed every year, with another 79 million people considered to be in a pre-diabetes state. These millions of people are at risk of several alterations, including heart disease, stroke, kidney failure, neuropathy, and blindness. Since diabetes has a major impact on the health of millions of people around the world, it is essential for nurses to understand the pathophysiology and associated alterations of this disorder. In this Discussion, you compare two types of diabetes—diabetes mellitus and diabetes insipidus.

To Prepare

Review Chapter 19 in the Huether and McCance text and Chapter 18 in the Hammer and McPhee text. Identify the pathophysiology of diabetes mellitus and diabetes insipidus. Consider the similarities and differences between resulting alterations of hormonal regulation.
Select two of the following patient factors: genetics, gender, ethnicity, age, or behavior. Think about how the factors you selected might impact the diagnosis and prescription of treatment for these two types of diabetes.
By Day 3
Post an explanation of the pathophysiology of diabetes mellitus and diabetes insipidus. Describe the differences and similarities between resulting alterations of hormonal regulation. Then explain how the factors you selected might impact the diagnosis and prescription of treatment for these two types of diabetes.

Note: For this Discussion, you are required to complete your initial post before you will be able to view and respond to your colleagues’ postings. Begin by clicking on the “Post to Discussion Question” link and then select “Create Thread” to complete your initial post. Remember, once you click on Submit, you cannot delete or edit your own posts, and you cannot post anonymously. Please check your post carefully before clicking on Submit!

4 reference not more than five years

zero plagiarism

Question

Question 1 1 / 1 point

Charlie is a 65-year-old male who has been diagnosed with hypertension and benign prostatic hyperplasia. Doxazosin has been chosen to treat his hypertension because it:

Question options:

Increases peripheral vasoconstriction

Decreases detrusor muscle contractility

Lowers supine blood pressure more than standing pressure

Relaxes smooth muscle in the bladder neck

Question 2 1 / 1 point

Which of the following adverse effects are less likely in a beta1-selective blocker?

Question options:

Dysrhythmias

Impaired insulin release

Reflex orthostatic changes

Decreased triglycerides and cholesterol

Question 3 1 / 1 point

Beta blockers have favorable effects on survival and disease progression in heart failure. Treatment should be initiated when the:

Question options:

Symptoms are severe

Patient has not responded to other therapies

Patient has concurrent hypertension

Left ventricular dysfunction is diagnosed

Question 4 1 / 1 point

You are treating a patient with a diagnosis of Alzheimer’s disease. The patient’s wife mentions difficulty with transportation to the clinic. Which medication is the best choice?

Question options:

Donepezil

Tacrine

Doxazosin

Verapamil

Question 5 1 / 1 point

Antonia is a 3-year-old child who has a history of status epilepticus. Along with her routine antiseizure medication, she should also have a home prescription for_________ to be used for an episode of status epilepticus.

Question options:

IV phenobarbital

Rectal diazepam (Diastat)

IV phenytoin (Dilantin)

Oral carbamazepine (Tegretol)

Question 6 1 / 1 point

Dwayne has recently started on carbamazepine to treat seizures. He comes to see you and you note that while his carbamazepine levels had been in the therapeutic range, they are now low. The possible cause for the low carbamazepine levels include:

Question options:

Dwayne hasn’t been taking his carbamazepine because it causes insomnia.

Carbamazepine auto-induces metabolism, leading to lower levels in spite of good compliance.

Dwayne was not originally prescribed the correct amount of carbamazepine.

Carbamazepine is probably not the right antiseizure medication for Dwayne.

Question 7 1 / 1 point

Kasey fractured his ankle in two places and is asking for medication for his pain. The appropriate first-line medication would be:

Question options:

Ibuprofen (Advil)

Acetaminophen with hydrocodone (Vicodin)

Oxycodone (Oxycontin)

Oral morphine (Roxanol)

Question 8 1 / 1 point

Jack, age 8, has attention deficit disorder (ADD) and is prescribed methylphenidate (Ritalin). He and his parents should be educated about the side effects of methylphenidate, which are:

Question options:

Slurred speech and insomnia

Bradycardia and confusion

Dizziness and orthostatic hypotension

Insomnia and decreased appetite

Question 9 1 / 1 point

An appropriate first-line drug to try for mild to moderate generalized anxiety disorder would be:

Question options:

Alprazolam (Xanax)

Diazepam (Valium)

Buspirone (Buspar)

Amitriptyline (Elavil)

Question 10 1 / 1 point

David is a 34-year-old patient who is starting on paroxetine (Paxil) for depression. David’s education regarding his medication would include:

Question options:

Paroxetine may cause intermittent diarrhea.

He may experience sexual dysfunction beginning a month after he starts therapy.

He may have constipation and he should increase fluids and fiber.

Paroxetine has a long half-life so he may occasionally skip a dose.

Question 11 1 / 1 point

An appropriate drug for the treatment of depression with anxiety would be:

Question options:

Alprazolam (Xanax)

Escitalopram (Lexapro)

Buspirone (Buspar)

Amitriptyline (Elavil)

Question 12 1 / 1 point

The longer-term Xanax patient comes in and states they need a higher dose of the medication. They deny any additional, new, or accelerating triggers of their anxiety. What is the probable reason?

Question options:

They have become tolerant of the medication, which is characterized by the need for higher and higher doses.

They are a drug seeker.

They are suicidal.

They only need additional counseling on lifestyle modification.

Question 13 1 / 1 point

A first-line drug for abortive therapy in simple migraine is:

Question options:

Sumatriptan (Imitrex)

Naproxen (Aleve)

Butorphanol nasal spray (Stadol NS)

Butalbital and acetaminophen (Fioricet)

Question 14 1 / 1 point

Xi, a 54-year-old female, has a history of migraines that do not respond well to OTC migraine medication. She is asking to try Maxalt (rizatriptan) because it works well for her friend. Appropriate decision making would be:

Question options:

Prescribe the Maxalt, but only give her four tablets with no refills to monitor the use.

Prescribe Maxalt and arrange to have her observed in the clinic or urgent care with the first dose.

Explain that rizatriptan is not used for postmenopausal migraines and recommend Fiorinal (aspirin and butalbital).

Prescribe sumatriptan (Imitrex) with the explanation that it is the most effective triptan.

Question 15 1 / 1 point

Kelly is a 14-year-old patient who presents to the clinic with a classic migraine. She says she is having a headache two to three times a month. The initial plan would be:

Question options:

Prescribe NSAIDs as abortive therapy and have her keep a headache diary to identify her triggers.

Prescribe zolmitriptan (Zomig) as abortive therapy and recommend relaxation therapy to reduce her stress.

Prescribe acetaminophen with codeine (Tylenol #3) for her to take at the first onset of her migraine.

Prescribe sumatriptan (Imitrex) nasal spray and arrange for her to receive the first dose in the clinic.

Question 16 1 / 1 point

James has been diagnosed with cluster headaches. Appropriate acute therapy would be:

Question options:

Butalbital and aspirin (Fiorinal)

Meperidine IM (Demerol)

Oxygen 100% for 15 to 30 minutes

Indomethacin (Indocin)

Question 17 1 / 1 point

If interventions to resolve the cause of pain (e.g., rest, ice, compression, and elevation) are insufficient, pain medications are given based on the severity of pain. Drugs are given in which order of use?

Question options:

NSAIDs, opiates, corticosteroids

Low-dose opiates, salicylates, increased dose of opiates

Opiates, non-opiates, increased dose of non-opiate

Non-opiate, increased dose of non-opiate, opiate

Question 18 1 / 1 point

Chemical dependency assessment is integral to the initial assessment of chronic pain. Which of the following raises a “red flag” about potential chemical dependency?

Question options:

Use of more than one drug to treat the pain

Multiple times when prescriptions are lost with requests to refill

Preferences for treatments that include alternative medicines

Presence of a family member who has abused drugs

Question 19 1 / 1 point

The Pain Management Contract is appropriate for:

Question options:

Patients with cancer who are taking morphine

Patients with chronic pain who will require long-term use of opiates

Patients who have a complex drug regimen

Patients who see multiple providers for pain control

Question 20 1 / 1 point

Which of the following statements is true about age and pain?

Question options:

Use of drugs that depend heavily on the renal system for excretion may require dosage adjustments in very young children.

Among the NSAIDs, indomethacin is the preferred drug because of lower adverse effects profiles than other NSAIDs.

Older adults who have dementia probably do not experience much pain due to loss of pain receptors in the brain.

Acetaminophen is especially useful in both children and adults because it has no effect on platelets and has fewer adverse effects than NSAIDs.

Lyme Disease

Case Study

A 38-year-old male had a 3-week history of fatigue and lethargy with intermittent complaints of headache, fever, chills, myalgia, and arthralgia. According to the history, the patient’s symptoms began shortly after a camping vacation. He recalled a bug bite and rash on his thigh immediately after the trip. The following studies were ordered:

Studies

Results

Lyme disease test,

Elevated IgM antibody titers against Borrelia burgdorferi (normal: low)

Erythrocyte sedimentation rate (ESR),

30 mm/hour (normal: ≤15 mm/hour)

Aspartate aminotransferase (AST),

32 units/L (normal: 8-20 units/L)

Hemoglobin (Hgb),

12 g/dL (normal: 14-18 g/dL)

Hematocrit (Hct),

36% (normal: 42%-52%)

Rheumatoid factor (RF),

Negative (normal: negative)

Antinuclear antibodies (ANA),

Negative (normal: negative)

Diagnostic Analysis

Based on the patient’s history of camping in the woods and an insect bite and rash on the thigh, Lyme disease was suspected. Early in the course of this disease, testing for specific immunoglobulin (Ig) M antibodies against B. burgdorferi is the most helpful in diagnosing Lyme disease. An elevated ESR, increased AST levels, and mild anemia are frequently seen early in this disease. RF and ANA abnormalities are usually absent.

Critical Thinking Questions

1. What is the cardinal sign of Lyme disease? (always on the boards)

2. At what stages of Lyme disease are the IgG and IgM antibodies elevated?

3. Why was the ESR elevated?

4. What is the Therapeutic goal for Lyme Disease and what is the recommended treatment.

Peripheral Vascular Disease

Case Studies

A 52-year-old man complained of pain and cramping in his right calf caused by walking two blocks. The pain was relieved with cessation of activity. The pain had been increasing in frequency and intensity. Physical examination findings were essentially normal except for decreased hair on the right leg. The patient’s popliteal, dorsalis pedis, and posterior tibial pulses were markedly decreased compared with those of his left leg.

Studies

Results

Routine laboratory work

Within normal limits (WNL)

Doppler ultrasound systolic pressures

Femoral: 130 mm Hg; popliteal: 90 mm Hg; posterior tibial: 88 mm Hg; dorsalis pedis: 88 mm Hg (normal: same as brachial systolic blood pressure)

Arterial plethysmography

Decreased amplitude of distal femoral, popliteal, dorsalis pedis, and posterior tibial pulse waves

Femoral arteriography of right leg

Obstruction of the femoral artery at the midthigh level

Arterial duplex scan

Apparent arterial obstruction in the superficial femoral artery

Diagnostic Analysis

With the clinical picture of classic intermittent claudication, the noninvasive Doppler and plethysmographic arterial vascular study merely documented the presence and location of the arterial occlusion in the proximal femoral artery. Most vascular surgeons prefer arteriography to document the location of the vascular occlusion. The patient underwent a bypass from the proximal femoral artery to the popliteal artery. After surgery he was asymptomatic.

Critical Thinking Questions

1. What was the cause of this patient’s pain and cramping?

2. Why was there decreased hair on the patient’s right leg?

3. What would be the strategic physical assessments after surgery to determine the adequacy of the patient’s circulation?

4. What would be the treatment of intermittent Claudication for non-occlusion?

how much would it cost to do the following:

 

How can graphics and/or statistics be used to misrepresent data? Where have you seen this done?

 

What are the characteristics of a population for which it would be appropriate to use mean/median/mode? When would the characteristics of a population make them inappropriate to use?

 

 

Questions to Be Graded: Exercises 6, 8 and 9 Complete Exercises 6, 8, and 9 in Statistics for Nursing Research: A Workbook for Evidence-Based Practice, and submit as directed by the instructor.	80.0
	Questions to Be Graded: Exercise 27 Use MS Word to complete “Questions to be Graded: Exercise 27” in Statistics for Nursing Research: A Workbook for Evidence-Based Practice. Submit your work in SPSS by copying the output and pasting into the Word document. In addition to the SPSS output, please include explanations of the results where appropriate.

 

 

 

 

 

 

 

 

 

 

 

 

 

Copyright © 2017, Elsevier Inc. All rights reserved. 67 EXERCISE 6 Questions to Be Graded Follow your instructor ’ s directions to submit your answers to the following questions for grading. Your instructor may ask you to write your answers below and submit them as a hard copy for grading. Alternatively, your instructor may ask you to use the space below for notes and submit your answers online at http://evolve.elsevier.com/Grove/statistics/ under “Questions to Be Graded.”

 

Name: _______________________________________________________

Class: _____________________

Date: ___________________________________________________________________________________ 68EXERCISE 6 •

 

 

1. What are the frequency and percentage of the COPD patients in the severe airfl ow limitation group who are employed in the Eckerblad et al. (2014) study?

 

2. What percentage of the total sample is retired? What percentage of the total sample is on sick leave?

 

3. What is the total sample size of this study? What frequency and percentage of the total sample were still employed? Show your calculations and round your answer to the nearest whole percent.

 

4. What is the total percentage of the sample with a smoking history—either still smoking or former smokers? Is the smoking history for study participants clinically important? Provide a rationale for your answer.

 

5. What are pack years of smoking? Is there a signifi cant difference between the moderate and severe airfl ow limitation groups regarding pack years of smoking? Provide a rationale for your answer.

 

6. What were the four most common psychological symptoms reported by this sample of patients with COPD? What percentage of these subjects experienced these symptoms? Was there a sig-nifi cant difference between the moderate and severe airfl ow limitation groups for psychological symptoms?

 

7. What frequency and percentage of the total sample used short-acting β 2 -agonists? Show your calculations and round to the nearest whole percent.

 

8. Is there a signifi cant difference between the moderate and severe airfl ow limitation groups regarding the use of short-acting β 2 -agonists? Provide a rationale for your answer.

9. Was the percentage of COPD patients with moderate and severe airfl ow limitation using short-acting β 2 -agonists what you expected? Provide a rationale with documentation for your answer.

 

10. Are these fi ndings ready for use in practice? Provide a rationale for your answer.

 

Understanding Frequencies and Percentages STATISTICAL TECHNIQUE IN REVIEW Frequency is the number of times a score or value for a variable occurs in a set of data. Frequency distribution is a statistical procedure that involves listing all the possible values or scores for a variable in a study. Frequency distributions are used to organize study data for a detailed examination to help determine the presence of errors in coding or computer programming ( Grove, Burns, & Gray, 2013 ). In addition, frequencies and percentages are used to describe demographic and study variables measured at the nominal or ordinal levels. Percentage can be defi ned as a portion or part of the whole or a named amount in every hundred measures. For example, a sample of 100 subjects might include 40 females and 60 males. In this example, the whole is the sample of 100 subjects, and gender is described as including two parts, 40 females and 60 males. A percentage is calculated by dividing the smaller number, which would be a part of the whole, by the larger number, which represents the whole. The result of this calculation is then multiplied by 100%. For example, if 14 nurses out of a total of 62 are working on a given day, you can divide 14 by 62 and multiply by 100% to calculate the percentage of nurses working that day. Calculations: (14 ÷ 62) × 100% = 0.2258 × 100% = 22.58% = 22.6%. The answer also might be expressed as a whole percentage, which would be 23% in this example. A cumulative percentage distribution involves the summing of percentages from the top of a table to the bottom. Therefore the bottom category has a cumulative percentage of 100% (Grove, Gray, & Burns, 2015). Cumulative percentages can also be used to deter-mine percentile ranks, especially when discussing standardized scores. For example, if 75% of a group scored equal to or lower than a particular examinee ’ s score, then that examinee ’ s rank is at the 75 th percentile. When reported as a percentile rank, the percentage is often rounded to the nearest whole number. Percentile ranks can be used to analyze ordinal data that can be assigned to categories that can be ranked. Percentile ranks and cumulative percentages might also be used in any frequency distribution where subjects have only one value for a variable. For example, demographic characteristics are usually reported with the frequency ( f ) or number ( n ) of subjects and percentage (%) of subjects for each level of a demographic variable. Income level is presented as an example for 200 subjects: Income Level Frequency ( f ) Percentage (%) Cumulative % 1. < $40,000 2010%10% 2. $40,000–$59,999 5025%35% 3. $60,000–$79,999 8040%75% 4. $80,000–$100,000 4020%95% 5. > $100,000 105%100% EXERCISE 6 60EXERCISE 6 • Understanding Frequencies and PercentagesCopyright © 2017, Elsevier Inc. All rights reserved. In data analysis, percentage distributions can be used to compare fi ndings from different studies that have different sample sizes, and these distributions are usually arranged in tables in order either from greatest to least or least to greatest percentages ( Plichta & Kelvin, 2013 ). RESEARCH ARTICLE Source Eckerblad, J., Tödt, K., Jakobsson, P., Unosson, M., Skargren, E., Kentsson, M., & Thean-der, K. (2014). Symptom burden in stable COPD patients with moderate to severe airfl ow limitation. Heart & Lung, 43 (4), 351–357. Introduction Eckerblad and colleagues (2014 , p. 351) conducted a comparative descriptive study to examine the symptoms of “patients with stable chronic obstructive pulmonary disease (COPD) and determine whether symptom experience differed between patients with mod-erate or severe airfl ow limitations.” The Memorial Symptom Assessment Scale (MSAS) was used to measure the symptoms of 42 outpatients with moderate airfl ow limitations and 49 patients with severe airfl ow limitations. The results indicated that the mean number of symptoms was 7.9 ( ± 4.3) for both groups combined, with no signifi cant dif-ferences found in symptoms between the patients with moderate and severe airfl ow limi-tations. For patients with the highest MSAS symptom burden scores in both the moderate and the severe limitations groups, the symptoms most frequently experienced included shortness of breath, dry mouth, cough, sleep problems, and lack of energy. The research-ers concluded that patients with moderate or severe airfl ow limitations experienced mul-tiple severe symptoms that caused high levels of distress. Quality assessment of COPD patients ’ physical and psychological symptoms is needed to improve the management of their symptoms. Relevant Study Results Eckerblad et al. (2014 , p. 353) noted in their research report that “In total, 91 patients assessed with MSAS met the criteria for moderate ( n = 42) or severe airfl ow limitations ( n = 49). Of those 91 patients, 47% were men, and 53% were women, with a mean age of 68 ( ± 7) years for men and 67 ( ± 8) years for women. The majority (70%) of patients were married or cohabitating. In addition, 61% were retired, and 15% were on sick leave. Twenty-eight percent of the patients still smoked, and 69% had stopped smoking. The mean BMI (kg/m 2 ) was 26.8 ( ± 5.7). There were no signifi cant differences in demographic characteristics, smoking history, or BMI between patients with moderate and severe airfl ow limitations ( Table 1 ). A lower proportion of patients with moderate airfl ow limitation used inhalation treatment with glucocorticosteroids, long-acting β 2 -agonists and short-acting β 2 -agonists, but a higher proportion used analgesics compared with patients with severe airfl ow limitation. Symptom prevalence and symptom experience The patients reported multiple symptoms with a mean number of 7.9 ( ± 4.3) symptoms (median = 7, range 0–32) for the total sample, 8.1 ( ± 4.4) for moderate airfl ow limitation and 7.7 ( ± 4.3) for severe airfl ow limitation ( p = 0.36) . . . . Highly prevalent physical symp-toms ( ≥ 50% of the total sample) were shortness of breath (90%), cough (65%), dry mouth (65%), and lack of energy (55%). Five additional physical symptoms, feeling drowsy Understanding Frequencies and Percentages • EXERCISE 6Copyright © 2017, Elsevier Inc. All rights reserved. TABLE 1 BACKGROUND CHARACTERISTICS AND USE OF MEDICATION FOR PATIENTS WITH STABLE CHRONIC OBSTRUCTIVE LUNG DISEASE CLASSIFIED IN PATIENTS WITH MODERATE AND SEVERE AIRFLOW LIMITATION Moderate n = 42 Severe n = 49 p Value Sex, n (%)0.607 Women19 (45)29 (59) Men23 (55)20 (41)Age (yrs), mean ( SD )66.5 (8.6)67.9 (6.8)0.396Married/cohabitant n (%)29 (69)34 (71)0.854Employed, n (%)7 (17)7 (14)0.754Smoking, n %0.789 Smoking13 (31)12 (24) Former smokers28 (67)35 (71) Never smokers1 (2)2 (4)Pack years smoking, mean ( SD )29.1 (13.5)34.0 (19.5)0.177BMI (kg/m 2 ), mean ( SD )27.2 (5.2)26.5 (6.1)0.555FEV 1 % of predicted, mean ( SD )61.6 (8.4)42.2 (5.8) < 0.001SpO 2 % mean ( SD )95.8 (2.4)94.5 (3.0)0.009Physical health, mean ( SD )3.2 (0.8)3.0 (0.8)0.120Mental health, mean ( SD )3.7 (0.9)3.6 (1.0)0.628Exacerbation previous 6 months, n (%)14 (33)15 (31)0.781Admitted to hospital previous year, n (%)10 (24)14 (29)0.607Medication use, n (%) Inhaled glucocorticosteroids30 (71)44 (90)0.025 Systemic glucocorticosteroids3 (6.3)0 (0)0.094 Anticholinergic32 (76)42 (86)0.245 Long-acting β 2 -agonists30 (71)45 (92)0.011 Short-acting β 2 -agonists13 (31)32 (65)0.001 Analgesics11 (26)5 (10)0.046 Statins8 (19)11 (23)0.691 Eckerblad, J., Tödt, K., Jakobsson, P., Unosson, M., Skargren, E., Kentsson, M., & Theander, K. (2014). Symptom burden in stable COPD patients with moderate to severe airfl ow limitation. Heart & Lung, 43 (4), p. 353. numbness/tingling in hands/feet, feeling irritable, and dizziness, were reported by between 25% and 50% of the patients. The most commonly reported psychological symptom was diffi culty sleeping (52%), followed by worrying (33%), feeling irritable (28%) and feeling sad (22%). There were no signifi cant differences in the occurrence of physical and psy-chological symptoms between patients with moderate and severe airfl ow limitations” ( Eckerblad et al., 2014 , p. 353). 62EXERCISE 6 • Understanding Frequencies and PercentagesCopyright © 2017, Elsevier Inc. All rights reserved. STUDY QUESTIONS 1. What are the frequency and percentage of women in the moderate airfl ow limitation group? 2. What were the frequencies and percentages of the moderate and the severe airfl ow limitation groups who experienced an exacerbation in the previous 6 months? 3. What is the total sample size of COPD patients included in this study? What number or fre-quency of the subjects is married/cohabitating? What percentage of the total sample is married or cohabitating? 4. Were the moderate and severe airfl ow limitation groups signifi cantly different regarding married/cohabitating status? Provide a rationale for your answer. 5. List at least three other relevant demographic variables the researchers might have gathered data on to describe this study sample. 6. For the total sample, what physical symptoms were experienced by ≥ 50% of the subjects? Identify the physical symptoms and the percentages of the total sample experiencing each symptom.

 

 

 

Interpreting Line Graphs EXERCISE 7

 

69 Interpreting Line Graphs STATISTICAL TECHNIQUE IN REVIEW Tables and fi gures are commonly used to present fi ndings from studies or to provide a way for researchers to become familiar with research data. Using fi gures, researchers are able to illustrate the results from descriptive data analyses, assist in identifying patterns in data, identify changes over time, and interpret exploratory fi ndings. A line graph is a fi gure that is developed by joining a series of plotted points with a line to illustrate how a variable changes over time. A line graph fi gure includes a horizontal scale, or x -axis, and a vertical scale, or y -axis. The x -axis is used to document time, and the y -axis is used to document the mean scores or values for a variable ( Grove, Burns, & Gray, 2013 ; Plichta & Kelvin, 2013 ). Researchers might include a line graph to compare the values for three or four variables in a study or to identify the changes in groups for a selected variable over time. For example, Figure 7-1 presents a line graph that documents time in weeks on the x -axis and mean weight loss in pounds on the y -axis for an experimental group consuming a low carbohydrate diet and a control group consuming a standard diet. This line graph illustrates the trend of a strong, steady increase in the mean weight lost by the experimental or intervention group and minimal mean weight loss by the control group. EXERCISE 7 FIGURE 7-1 ■ LINE GRAPH COMPARING EXPERIMENTAL AND CONTROL GROUPS FOR WEIGHT LOSS OVER FOUR WEEKS. Weight loss (lbs)Weeksy-axisx-axisControlExperimental10864201234 70EXERCISE 7 • Interpreting Line GraphsCopyright © 2017, Elsevier Inc. All rights reserved. RESEARCH ARTICLE Source Azzolin, K., Mussi, C. M., Ruschel, K. B., de Souza, E. N., Lucena, A. D., & Rabelo-Silva, E. R. (2013). Effectiveness of nursing interventions in heart failure patients in home care using NANDA-I, NIC, and NOC. Applied Nursing Research, 26 (4), 239–244. Introduction Azzolin and colleagues (2013) analyzed data from a larger randomized clinical trial to determine the effectiveness of 11 nursing interventions (NIC) on selected nursing out-comes (NOC) in a sample of patients with heart failure (HF) receiving home care. A total of 23 patients with HF were followed for 6 months after hospital discharge and provided four home visits and four telephone calls. The home visits and phone calls were organized using the nursing diagnoses from the North American Nursing Diagnosis Association International (NANDA-I) classifi cation list. The researchers found that eight nursing interven tions signifi cantly improved the nursing outcomes for these HF patients. Those interventions included “health education, self-modifi cation assistance, behavior modifi -cation, telephone consultation, nutritional counselling, teaching: prescribed medications, teaching: disease process, and energy management” ( Azzolin et al., 2013 , p. 243). The researchers concluded that the NANDA-I, NIC, and NOC linkages were useful in manag-ing patients with HF in their home. Relevant Study Results Azzolin and colleagues (2013) presented their results in a line graph format to display the nursing outcome changes over the 6 months of the home visits and phone calls. The nursing outcomes were measured with a fi ve-point Likert scale with 1 = worst and 5 = best. “Of the eight outcomes selected and measured during the visits, four belonged to the health & knowledge behavior domain (50%), as follows: knowledge: treatment regimen; compliance behavior; knowledge: medication; and symptom control. Signifi cant increases were observed in this domain for all outcomes when comparing mean scores obtained at visits no. 1 and 4 ( Figure 1 ; p < 0.001 for all comparisons). The other four outcomes assessed belong to three different NOC domains, namely, functional health (activity tolerance and energy conservation), physiologic health (fl uid balance), and family health (family participation in professional care). The scores obtained for activity tolerance and energy conservation increased signifi cantly from visit no. 1 to visit no. 4 ( p = 0.004 and p < 0.001, respectively). Fluid balance and family participation in professional care did not show statistically signifi cant differences ( p = 0.848 and p = 0.101, respectively) ( Figure 2 )” ( Azzolin et al., 2013 , p. 241). The signifi cance level or alpha ( α ) was set at 0.05 for this study. Interpreting Line Graphs • EXERCISE 7Copyright © 2017, Elsevier Inc. All rights reserved. FIGURE 2 ■ NURSING OUTCOMES MEASURED OVER 6 MONTHS (OTHER DOMAINS): Activity tolerance (95% CI − 1.38 to − 0.18, p = 0.004); energy conservation (95% CI − 0.62 to − 0.19, p < 0.001); fl uid balance (95% CI − 0.25 to 0.07, p = .848); family participation in professional care (95% CI − 2.31 to − 0.11, p = 0.101). HV = home visit. CI = confi dence interval. Azzolin, K., Mussi, C. M., Ruschel, K. B., de Souza, E. N., Lucena, A. D., & Rabelo-Silva, E. R. (2013). Effectiveness of nursing interventions in heart failure patients in home care using NANDA-I, NIC, and NOC. Applied Nursing Research, 26 (4), p. 242. 5.04.54.03.53.02.52.01.51.00.50MeanHV1HV2HV3HV4Fluid balanceFamily participationin professional careActivity toleranceEnergy conservation FIGURE 1 ■ NURSING OUTCOMES MEASURED OVER 6 MONTHS (HEALTH & KNOWLEDGE BEHAVIOR DOMAIN): Knowledge: medication (95% CI − 1.66 to − 0.87, p < 0.001); knowledge: treatment regimen (95% CI − 1.53 to − 0.98, p < 0.001); symptom control (95% CI − 1.93 to − 0.95, p < 0.001); and compliance behavior (95% CI − 1.24 to − 0.56, p < 0.001). HV = home visit. CI = confi dence interval. 5.04.54.03.53.02.52.01.51.00.50MeanHV1HV2HV3HV4Compliance behaviorSymptom controlKnowledge: medicationKnowledge: treatment reg 72EXERCISE 7 • Interpreting Line GraphsCopyright © 2017, Elsevier Inc. All rights reserved. STUDY QUESTIONS 1. What is the purpose of a line graph? What elements are included in a line graph? 2. Review Figure 1 and identify the focus of the x -axis and the y -axis. What is the time frame for the x -axis? What variables are presented on this line graph? 3. In Figure 1 , did the nursing outcome compliance behavior change over the 6 months of home visits? Provide a rationale for your answer. 4. State the null hypothesis for the nursing outcome compliance behavior. 5. Was there a signifi cant difference in compliance behavior from the fi rst home visit (HV1) to the fourth home visit (HV4)? Was the null hypothesis accepted or rejected? Provide a rationale for your answer. 6. In Figure 1 , what outcome had the lowest mean at HV1? Did this outcome improve over the four home visits? Provide a rationale for your answer.

 

 

Copyright © 2017, Elsevier Inc. All rights reserved. 77

 

Questions to Be Graded EXERCISE 7 Follow your instructor ’ s directions to submit your answers to the following questions for grading. Your instructor may ask you to write your answers below and submit them as a hard copy for grading. Alternatively, your instructor may ask you to use the space below for notes and submit your answers online at http://evolve.elsevier.com/Grove/statistics/ under “Questions to Be Graded.”

 

1. What is the focus of the example Figure 7-1 in the section introducing the statistical technique of this exercise?

 

2. In Figure 2 of the Azzolin et al. (2013 , p. 242) study, did the nursing outcome activity tolerance change over the 6 months of home visits (HVs) and telephone calls? Provide a rationale for your answer.

 

3. State the null hypothesis for the nursing outcome activity tolerance.

 

4. Was there a signifi cant difference in activity tolerance from the fi rst home visit (HV1) to the fourth home visit (HV4)? Was the null hypothesis accepted or rejected? Provide a rationale for your answer.

 

5. In Figure 2 , what nursing outcome had the lowest mean at HV1? Did this outcome improve over the four HVs? Provide a rationale for your answer.

 

6. What nursing outcome had the highest mean at HV1 and at HV4? Was this outcome signifi -cantly different from HV1 to HV4? Provide a rationale for your answer.

 

 

 

 

 

7. State the null hypothesis for the nursing outcome family participation in professional care.

 

8. Was there a statistically signifi cant difference in family participation in professional care from HV1 to HV4? Was the null hypothesis accepted or rejected? Provide a rationale for your answer.

 

9. Was Figure 2 helpful in understanding the nursing outcomes for patients with heart failure (HF) who received four HVs and telephone calls? Provide a rationale for your answer. 10. What nursing interventions signifi cantly improved the nursing outcomes for these patients with HF? What implications for practice do you note from these study results? Copyright © 2017, Elsevier Inc. All rights reserved. 79 Measures of Central Tendency : Mean, Median, and Mode

 

 

EXERCISE 8 STATISTICAL TECHNIQUE IN REVIEW Mean, median, and mode are the three measures of central tendency used to describe study variables. These statistical techniques are calculated to determine the center of a distribution of data, and the central tendency that is calculated is determined by the level of measurement of the data (nominal, ordinal, interval, or ratio; see Exercise 1 ). The mode is a category or score that occurs with the greatest frequency in a distribution of scores in a data set. The mode is the only acceptable measure of central tendency for analyzing nominal-level data, which are not continuous and cannot be ranked, compared, or sub-jected to mathematical operations. If a distribution has two scores that occur more fre-quently than others (two modes), the distribution is called bimodal . A distribution with more than two modes is multimodal ( Grove, Burns, & Gray, 2013 ). The median ( MD ) is a score that lies in the middle of a rank-ordered list of values of a distribution. If a distribution consists of an odd number of scores, the MD is the middle score that divides the rest of the distribution into two equal parts, with half of the values falling above the middle score and half of the values falling below this score. In a distribu-tion with an even number of scores, the MD is half of the sum of the two middle numbers of that distribution. If several scores in a distribution are of the same value, then the MD will be the value of the middle score. The MD is the most precise measure of central ten-dency for ordinal-level data and for nonnormally distributed or skewed interval- or ratio-level data. The following formula can be used to calculate a median in a distribution of scores. Median()()MDN=+÷12 N is the number of scores ExampleMedianscoreth:N==+=÷=31311232216 ExampleMedianscoreth:.N==+=÷=404012412205 Thus in the second example, the median is halfway between the 20 th and the 21 st scores. The mean ( X ) is the arithmetic average of all scores of a sample, that is, the sum of its individual scores divided by the total number of scores. The mean is the most accurate measure of central tendency for normally distributed data measured at the interval and ratio levels and is only appropriate for these levels of data (Grove, Gray, & Burns, 2015). In a normal distribution, the mean, median, and mode are essentially equal (see Exercise 26 for determining the normality of a distribution). The mean is sensitive to extreme

 

Copyright © 2017, Elsevier Inc. All rights reserved. 77 Questions to Be Graded EXERCISE 7 Follow your instructor ’ s directions to submit your answers to the following questions for grading. Your instructor may ask you to write your answers below and submit them as a hard copy for grading. Alternatively, your instructor may ask you to use the space below for notes and submit your answers online at http://evolve.elsevier.com/Grove/statistics/ under “Questions to Be Graded.” 1. What is the focus of the example Figure 7-1 in the section introducing the statistical technique of this exercise? 2. In Figure 2 of the Azzolin et al. (2013 , p. 242) study, did the nursing outcome activity tolerance change over the 6 months of home visits (HVs) and telephone calls? Provide a rationale for your answer. 3. State the null hypothesis for the nursing outcome activity tolerance. 4. Was there a signifi cant difference in activity tolerance from the fi rst home visit (HV1) to the fourth home visit (HV4)? Was the null hypothesis accepted or rejected? Provide a rationale for your answer. Name: _______________________________________________________ Class: _____________________ Date: ___________________________________________________________________________________ 78EXERCISE 7 • Interpreting Line GraphsCopyright © 2017, Elsevier Inc. All rights reserved. 5. In Figure 2 , what nursing outcome had the lowest mean at HV1? Did this outcome improve over the four HVs? Provide a rationale for your answer. 6. What nursing outcome had the highest mean at HV1 and at HV4? Was this outcome signifi -cantly different from HV1 to HV4? Provide a rationale for your answer. 7. State the null hypothesis for the nursing outcome family participation in professional care. 8. Was there a statistically signifi cant difference in family participation in professional care from HV1 to HV4? Was the null hypothesis accepted or rejected? Provide a rationale for your answer. 9. Was Figure 2 helpful in understanding the nursing outcomes for patients with heart failure (HF) who received four HVs and telephone calls? Provide a rationale for your answer. 10. What nursing interventions signifi cantly improved the nursing outcomes for these patients with HF? What implications for practice do you note from these study results? Copyright © 2017, Elsevier Inc. All rights reserved. 79 Measures of Central Tendency : Mean, Median, and Mode EXERCISE 8 STATISTICAL TECHNIQUE IN REVIEW Mean, median, and mode are the three measures of central tendency used to describe study variables. These statistical techniques are calculated to determine the center of a distribution of data, and the central tendency that is calculated is determined by the level of measurement of the data (nominal, ordinal, interval, or ratio; see Exercise 1 ). The mode is a category or score that occurs with the greatest frequency in a distribution of scores in a data set. The mode is the only acceptable measure of central tendency for analyzing nominal-level data, which are not continuous and cannot be ranked, compared, or sub-jected to mathematical operations. If a distribution has two scores that occur more fre-quently than others (two modes), the distribution is called bimodal . A distribution with more than two modes is multimodal ( Grove, Burns, & Gray, 2013 ). The median ( MD ) is a score that lies in the middle of a rank-ordered list of values of a distribution. If a distribution consists of an odd number of scores, the MD is the middle score that divides the rest of the distribution into two equal parts, with half of the values falling above the middle score and half of the values falling below this score. In a distribu-tion with an even number of scores, the MD is half of the sum of the two middle numbers of that distribution. If several scores in a distribution are of the same value, then the MD will be the value of the middle score. The MD is the most precise measure of central ten-dency for ordinal-level data and for nonnormally distributed or skewed interval- or ratio-level data. The following formula can be used to calculate a median in a distribution of scores. Median()()MDN=+÷12 N is the number of scores ExampleMedianscoreth:N==+=÷=31311232216 ExampleMedianscoreth:.N==+=÷=404012412205 Thus in the second example, the median is halfway between the 20 th and the 21 st scores. The mean ( X ) is the arithmetic average of all scores of a sample, that is, the sum of its individual scores divided by the total number of scores. The mean is the most accurate measure of central tendency for normally distributed data measured at the interval and ratio levels and is only appropriate for these levels of data (Grove, Gray, & Burns, 2015). In a normal distribution, the mean, median, and mode are essentially equal (see Exercise 26 for determining the normality of a distribution). The mean is sensitive to extreme

 

 

 

Copyright © 2017, Elsevier Inc. All rights reserved. 77 Questions to Be Graded EXERCISE 7 Follow your instructor ’ s directions to submit your answers to the following questions for grading. Your instructor may ask you to write your answers below and submit them as a hard copy for grading. Alternatively, your instructor may ask you to use the space below for notes and submit your answers online at http://evolve.elsevier.com/Grove/statistics/ under “Questions to Be Graded.”

 

1. What is the focus of the example Figure 7-1 in the section introducing the statistical technique of this exercise?

 

2. In Figure 2 of the Azzolin et al. (2013 , p. 242) study, did the nursing outcome activity tolerance change over the 6 months of home visits (HVs) and telephone calls? Provide a rationale for your answer.

 

3. State the null hypothesis for the nursing outcome activity tolerance.

 

4. Was there a signifi cant difference in activity tolerance from the fi rst home visit (HV1) to the fourth home visit (HV4)? Was the null hypothesis accepted or rejected? Provide a rationale for your answer.

 

5. In Figure 2 , what nursing outcome had the lowest mean at HV1? Did this outcome improve over the four HVs? Provide a rationale for your answer.

 

6. What nursing outcome had the highest mean at HV1 and at HV4? Was this outcome signifi -cantly different from HV1 to HV4? Provide a rationale for your answer.

 

7. State the null hypothesis for the nursing outcome family participation in professional care.

 

8. Was there a statistically signifi cant difference in family participation in professional care from HV1 to HV4? Was the null hypothesis accepted or rejected? Provide a rationale for your answer.

9. Was Figure 2 helpful in understanding the nursing outcomes for patients with heart failure (HF) who received four HVs and telephone calls? Provide a rationale for your answer.

 

10. What nursing interventions signifi cantly improved the nursing outcomes for these patients with HF? What implications for practice do you note from these study results?

 

 

Copyright © 2017, Elsevier Inc. All rights reserved. 79 Measures of Central Tendency : Mean, Median, and Mode EXERCISE 8 STATISTICAL TECHNIQUE IN REVIEW Mean, median, and mode are the three measures of central tendency used to describe study variables. These statistical techniques are calculated to determine the center of a distribution of data, and the central tendency that is calculated is determined by the level of measurement of the data (nominal, ordinal, interval, or ratio; see Exercise 1 ). The mode is a category or score that occurs with the greatest frequency in a distribution of scores in a data set. The mode is the only acceptable measure of central tendency for analyzing nominal-level data, which are not continuous and cannot be ranked, compared, or sub-jected to mathematical operations. If a distribution has two scores that occur more fre-quently than others (two modes), the distribution is called bimodal . A distribution with more than two modes is multimodal ( Grove, Burns, & Gray, 2013 ). The median ( MD ) is a score that lies in the middle of a rank-ordered list of values of a distribution. If a distribution consists of an odd number of scores, the MD is the middle score that divides the rest of the distribution into two equal parts, with half of the values falling above the middle score and half of the values falling below this score. In a distribu-tion with an even number of scores, the MD is half of the sum of the two middle numbers of that distribution. If several scores in a distribution are of the same value, then the MD will be the value of the middle score. The MD is the most precise measure of central ten-dency for ordinal-level data and for nonnormally distributed or skewed interval- or ratio-level data. The following formula can be used to calculate a median in a distribution of scores. Median()()MDN=+÷12 N is the number of scores ExampleMedianscoreth:N==+=÷=31311232216 ExampleMedianscoreth:.N==+=÷=404012412205 Thus in the second example, the median is halfway between the 20 th and the 21 st scores. The mean ( X ) is the arithmetic average of all scores of a sample, that is, the sum of its individual scores divided by the total number of scores. The mean is the most accurate measure of central tendency for normally distributed data measured at the interval and ratio levels and is only appropriate for these levels of data (Grove, Gray, & Burns, 2015). In a normal distribution, the mean, median, and mode are essentially equal (see Exercise 26 for determining the normality of a distribution). The mean is sensitive to extreme

 

 

 

 

 

 

 

Copyright © 2017, Elsevier Inc. All rights reserved. 291

 

Calculating Descriptive Statistics

 

There are two major classes of statistics: descriptive statistics and inferential statistics. Descriptive statistics are computed to reveal characteristics of the sample data set and to describe study variables. Inferential statistics are computed to gain information about effects and associations in the population being studied. For some types of studies, descriptive statistics will be the only approach to analysis of the data. For other studies, descriptive statistics are the fi rst step in the data analysis process, to be followed by infer-ential statistics. For all studies that involve numerical data, descriptive statistics are crucial in understanding the fundamental properties of the variables being studied. Exer-cise 27 focuses only on descriptive statistics and will illustrate the most common descrip-tive statistics computed in nursing research and provide examples using actual clinical data from empirical publications. MEASURES OF CENTRAL TENDENCY A measure of central tendency is a statistic that represents the center or middle of a frequency distribution. The three measures of central tendency commonly used in nursing research are the mode, median ( MD ), and mean ( X ). The mean is the arithmetic average of all of a variable ’ s values. The median is the exact middle value (or the average of the middle two values if there is an even number of observations). The mode is the most commonly occurring value or values (see Exercise 8 ). The following data have been collected from veterans with rheumatoid arthritis ( Tran, Hooker, Cipher, & Reimold, 2009 ). The values in Table 27-1 were extracted from a larger sample of veterans who had a history of biologic medication use (e.g., infl iximab [Remi-cade], etanercept [Enbrel]). Table 27-1 contains data collected from 10 veterans who had stopped taking biologic medications, and the variable represents the number of years that each veteran had taken the medication before stopping. Because the number of study subjects represented below is 10, the correct statistical notation to refl ect that number is: n=10 Note that the n is lowercase, because we are referring to a sample of veterans. If the data being presented represented the entire population of veterans, the correct notation is the uppercase N. Because most nursing research is conducted using samples, not popu-lations, all formulas in the subsequent exercises will incorporate the sample notation, n. Mode The mode is the numerical value or score that occurs with the greatest frequency; it does not necessarily indicate the center of the data set. The data in Table 27-1 contain two EXERCISE 27 292EXERCISE 27 • Calculating Descriptive StatisticsCopyright © 2017, Elsevier Inc. All rights reserved. modes: 1.5 and 3.0. Each of these numbers occurred twice in the data set. When two modes exist, the data set is referred to as bimodal ; a data set that contains more than two modes would be multimodal . Median The median ( MD ) is the score at the exact center of the ungrouped frequency distribution. It is the 50th percentile. To obtain the MD , sort the values from lowest to highest. If the number of values is an uneven number, exactly 50% of the values are above the MD and 50% are below it. If the number of values is an even number, the MD is the average of the two middle values. Thus the MD may not be an actual value in the data set. For example, the data in Table 27-1 consist of 10 observations, and therefore the MD is calculated as the average of the two middle values. MD=+()=15202175… Mean The most commonly reported measure of central tendency is the mean. The mean is the sum of the scores divided by the number of scores being summed. Thus like the MD, the mean may not be a member of the data set. The formula for calculating the mean is as follows: XXn=∑ where X = mean ∑ = sigma, the statistical symbol for summation X = a single value in the sample n = total number of values in the sample The mean number of years that the veterans used a biologic medication is calculated as follows: X=+++++++++()=010313151520223030401019………..years TABLE 27-1 DURATION OF BIOLOGIC USE AMONG VETERANS WITH RHEUMATOID ARTHRITIS ( n = 10) Duration of Biologic Use (years) 0.10.31.31.51.52.02.23.03.04.0 293Calculating Descriptive Statistics • EXERCISE 27Copyright © 2017, Elsevier Inc. All rights reserved. The mean is an appropriate measure of central tendency for approximately normally distributed populations with variables measured at the interval or ratio level. It is also appropriate for ordinal level data such as Likert scale values, where higher numbers rep-resent more of the construct being measured and lower numbers represent less of the construct (such as pain levels, patient satisfaction, depression, and health status). The mean is sensitive to extreme scores such as outliers. An outlier is a value in a sample data set that is unusually low or unusually high in the context of the rest of the sample data. An example of an outlier in the data presented in Table 27-1 might be a value such as 11. The existing values range from 0.1 to 4.0, meaning that no veteran used a biologic beyond 4 years. If an additional veteran were added to the sample and that person used a biologic for 11 years, the mean would be much larger: 2.7 years. Simply adding this outlier to the sample nearly doubled the mean value. The outlier would also change the frequency distribution. Without the outlier, the frequency distribution is approximately normal, as shown in Figure 27-1 . Including the outlier changes the shape of the distribution to appear positively skewed. Although the use of summary statistics has been the traditional approach to describing data or describing the characteristics of the sample before inferential statistical analysis, its ability to clarify the nature of data is limited. For example, using measures of central tendency, particularly the mean, to describe the nature of the data obscures the impact of extreme values or deviations in the data. Thus, signifi cant features in the data may be concealed or misrepresented. Often, anomalous, unexpected, or problematic data and discrepant patterns are evident, but are not regarded as meaningful. Measures of disper-sion, such as the range, difference scores, variance, and standard deviation ( SD ), provide important insight into the nature of the data. MEASURES OF DISPERSION Measures of dispersion , or variability, are measures of individual differences of the members of the population and sample. They indicate how values in a sample are dis-persed around the mean. These measures provide information about the data that is not available from measures of central tendency. They indicate how different the scores are—the extent to which individual values deviate from one another. If the individual values are similar, measures of variability are small and the sample is relatively homogeneous in terms of those values. Heterogeneity (wide variation in scores) is important in some statistical procedures, such as correlation. Heterogeneity is determined by measures of variability. The measures most commonly used are range, difference scores, variance, and SD (see Exercise 9 ). FIGURE 27-1 ■ FREQUENCY DISTRIBUTION OF YEARS OF BIOLOGIC USE, WITHOUT OUTLIER AND WITH OUTLIER. 0FrequencyFrequency3-3.90-0.92-2.91-1.94-4.93-3.90-.91-1.92-2.94-4.95-5.96-6.97-7.98-8.99-9.910-10.911-11.9Years of biologic useYears of biologic use3.02.52.01.51.00.503.02.52.01.51.00.5 294EXERCISE 27 • Calculating Descriptive StatisticsCopyright © 2017, Elsevier Inc. All rights reserved. Range The simplest measure of dispersion is the range . In published studies, range is presented in two ways: (1) the range is the lowest and highest scores, or (2) the range is calculated by subtracting the lowest score from the highest score. The range for the scores in Table 27-1 is 0.3 and 4.0, or it can be calculated as follows: 4.0 − 0.3 = 3.7. In this form, the range is a difference score that uses only the two extreme scores for the comparison. The range is generally reported but is not used in further analyses. Difference Scores Difference scores are obtained by subtracting the mean from each score. Sometimes a difference score is referred to as a deviation score because it indicates the extent to which a score deviates from the mean. Of course, most variables in nursing research are not “scores,” yet the term difference score is used to represent a value ’ s deviation from the mean. The difference score is positive when the score is above the mean, and it is negative when the score is below the mean (see Table 27-2 ). Difference scores are the basis for many statistical analyses and can be found within many statistical equations. The formula for difference scores is: XX− Σof absolute values95:. TABLE 27-2 DIFFERENCE SCORES OF DURATION OF BIOLOGIC USE X –X XX– 0.1 − 1.9 − 1.80.3 − 1.9 − 1.61.3 − 1.9 − 0.61.5 − 1.9 − 0.41.5 − 1.9 − 0.42.0 − 1.90.12.2 − 1.90.33.0 − 1.91.13.0 − 1.91.14.0 − 1.92.1 The mean deviation is the average difference score, using the absolute values. The formula for the mean deviation is: XXXndeviation=−∑ In this example, the mean deviation is 0.95. This value was calculated by taking the sum of the absolute value of each difference score (1.8, 1.6, 0.6, 0.4, 0.4, 0.1, 0.3, 1.1, 1.1, 2.1) and dividing by 10. The result indicates that, on average, subjects ’ duration of biologic use deviated from the mean by 0.95 years. Variance Variance is another measure commonly used in statistical analysis. The equation for a sample variance ( s 2 ) is below. sXXn221=−()−∑ 295Calculating Descriptive Statistics • EXERCISE 27Copyright © 2017, Elsevier Inc. All rights reserved. Note that the lowercase letter s 2 is used to represent a sample variance. The lowercase Greek sigma ( σ 2 ) is used to represent a population variance, in which the denominator is N instead of n − 1. Because most nursing research is conducted using samples, not popu-lations, formulas in the subsequent exercises that contain a variance or standard deviation will incorporate the sample notation, using n − 1 as the denominator. Moreover, statistical software packages compute the variance and standard deviation using the sample formu-las, not the population formulas. The variance is always a positive value and has no upper limit. In general, the larger the variance, the larger the dispersion of scores. The variance is most often computed to derive the standard deviation because, unlike the variance, the standard deviation refl ects impor-tant properties about the frequency distribution of the variable it represents. Table 27-3 displays how we would compute a variance by hand, using the biologic duration data. s213419=. s²=1.49 TABLE 27-3 VARIANCE COMPUTATION OF BIOLOGIC USE X X XX– XX–(())2 0.1 − 1.9 − 1.83.240.3 − 1.9 − 1.62.561.3 − 1.9 − 0.60.361.5 − 1.9 − 0.40.161.5 − 1.9 − 0.40.162.0 − 1.90.10.012.2 − 1.90.30.093.0 − 1.91.11.213.0 − 1.91.11.214.0 − 1.92.14.41 Σ 13.41 Standard Deviation Standard deviation is a measure of dispersion that is the square root of the variance. The standard deviation is represented by the notation s or SD . The equation for obtaining a standard deviation is SDX=−()−∑Xn21 Table 27-3 displays the computations for the variance. To compute the SD , simply take the square root of the variance. We know that the variance of biologic duration is s 2 = 1.49. Therefore, the s of biologic duration is SD = 1.22. The SD is an important sta-tistic, both for understanding dispersion within a distribution and for interpreting the relationship of a particular value to the distribution. SAMPLING ERROR A standard error describes the extent of sampling error. For example, a standard error of the mean is calculated to determine the magnitude of the variability associated with the mean. A small standard error is an indication that the sample mean is close to 296EXERCISE 27 • Calculating Descriptive StatisticsCopyright © 2017, Elsevier Inc. All rights reserved. the population mean, while a large standard error yields less certainty that the sample mean approximates the population mean. The formula for the standard error of the mean ( sX ) is: ssnX= Using the biologic medication duration data, we know that the standard deviation of biologic duration is s = 1.22. Therefore, the standard error of the mean for biologic dura-tion is computed as follows: sX=12210. sX=039. The standard error of the mean for biologic duration is 0.39. Confi dence Intervals To determine how closely the sample mean approximates the population mean, the stan-dard error of the mean is used to build a confi dence interval. For that matter, a confi dence interval can be created for many statistics, such as a mean, proportion, and odds ratio. To build a confi dence interval around a statistic, you must have the standard error value and the t value to adjust the standard error. The degrees of freedom ( df ) to use to compute a confi dence interval is df = n − 1. To compute the confi dence interval for a mean, the lower and upper limits of that interval are created by multiplying the sX by the t statistic, where df = n − 1. For a 95% confi dence interval, the t value should be selected at α = 0.05. For a 99% confi dence inter-val, the t value should be selected at α = 0.01. Using the biologic medication duration data, we know that the standard error of the mean duration of biologic medication use is sX=039. . The mean duration of biologic medication use is 1.89. Therefore, the 95% confi dence interval for the mean duration of biologic medication use is computed as follows: XstX± 189039226…±()() 189088..± As referenced in Appendix A , the t value required for the 95% confi dence interval with df = 9 is 2.26. The computation above results in a lower limit of 1.01 and an upper limit of 2.77. This means that our confi dence interval of 1.01 to 2.77 estimates the population mean duration of biologic use with 95% confi dence ( Kline, 2004 ). Technically and math-ematically, it means that if we computed the mean duration of biologic medication use on an infi nite number of veterans, exactly 95% of the intervals would contain the true population mean, and 5% would not contain the population mean ( Gliner, Morgan, & Leech, 2009 ). If we were to compute a 99% confi dence interval, we would require the t value that is referenced at α = 0.01. Therefore, the 99% confi dence interval for the mean duration of biologic medication use is computed as follows: 189039325…±()() 189127..± 297Calculating Descriptive Statistics • EXERCISE 27Copyright © 2017, Elsevier Inc. All rights reserved. As referenced in Appendix A , the t value required for the 99% confi dence interval with df = 9 is 3.25. The computation above results in a lower limit of 0.62 and an upper limit of 3.16. This means that our confi dence interval of 0.62 to 3.16 estimates the population mean duration of biologic use with 99% confi dence. Degrees of Freedom The concept of degrees of freedom ( df ) was used in reference to computing a confi dence interval. For any statistical computation, degrees of freedom are the number of inde-pendent pieces of information that are free to vary in order to estimate another piece of information ( Zar, 2010 ). In the case of the confi dence interval, the degrees of freedom are n − 1. This means that there are n − 1 independent observations in the sample that are free to vary (to be any value) to estimate the lower and upper limits of the confi dence interval. SPSS COMPUTATIONS A retrospective descriptive study examined the duration of biologic use from veterans with rheumatoid arthritis ( Tran et al., 2009 ). The values in Table 27-4 were extracted from a larger sample of veterans who had a history of biologic medication use (e.g., infl iximab [Remicade], etanercept [Enbrel]). Table 27-4 contains simulated demographic data col-lected from 10 veterans who had stopped taking biologic medications. Age at study enroll-ment, duration of biologic use, race/ethnicity, gender (F = female), tobacco use (F = former use, C = current use, N = never used), primary diagnosis (3 = irritable bowel syndrome, 4 = psoriatic arthritis, 5 = rheumatoid arthritis, 6 = reactive arthritis), and type of biologic medication used were among the study variables examined. TABLE 27-4 DEMOGRAPHIC VARIABLES OF VETERANS WITH RHEUMATOID ARTHRITIS Patient ID Duration (yrs) Age Race/Ethnicity Gender Tobacco Diagnosis Biologic 10.142CaucasianFF5Infl iximab20.341Black, not of Hispanic OriginFF5Etanercept31.356CaucasianFN5Infl iximab41.578CaucasianFF3Infl iximab51.586Black, not of Hispanic OriginFF4Etanercept62.049CaucasianFF6Etanercept72.282CaucasianFF5Infl iximab83.035CaucasianFN3Infl iximab93.059Black, not of Hispanic OriginFC3Infl iximab104.037CaucasianFF5Etanercept 298EXERCISE 27 • Calculating Descriptive StatisticsCopyright © 2017, Elsevier Inc. All rights reserved. This is how our data set looks in SPSS. Step 1: For a nominal variable, the appropriate descriptive statistics are frequencies and percentages. From the “Analyze” menu, choose “Descriptive Statistics” and “Frequen-cies.” Move “Race/Ethnicity and Gender” over to the right. Click “OK.” 299Calculating Descriptive Statistics • EXERCISE 27Copyright © 2017, Elsevier Inc. All rights reserved. Step 2: For a continuous variable, the appropriate descriptive statistics are means and standard deviations. From the “Analyze” menu, choose “Descriptive Statistics” and “Explore.” Move “Duration” over to the right. Click “OK.” INTERPRETATION OF SPSS OUTPUT The following tables are generated from SPSS. The fi rst set of tables (from the fi rst set of SPSS commands in Step 1) contains the frequencies of race/ethnicity and gender. Most (70%) were Caucasian, and 100% were female. Frequencies Frequency Table RaceEthnicityFrequencyPercentValid PercentCumulative PercentValidBlack, not of Hispanic Origin330.030.030.0Caucasian770.070.0100.0Total10100.0100.0GenderFrequencyPercentValid PercentCumulative PercentValidF10100.0100.0100.0 300EXERCISE 27 • Calculating Descriptive StatisticsCopyright © 2017, Elsevier Inc. All rights reserved. DescriptivesStatisticStd. ErrorDuration of Biologic Use1.890.3860Lower Bound1.017Upper Bound2.7631.8721.7501.4901.2206.14.03.92.0.159.687-.4371.334Mean95% Confidence Interval for Mean 5% Trimmed MeanMedianVarianceStd. DeviationMinimumMaximumRangeInterquartile RangeSkewnessKurtosis The second set of output (from the second set of SPSS commands in Step 2) contains the descriptive statistics for “Duration,” including the mean, s (standard deviation), SE , 95% confi dence interval for the mean, median, variance, minimum value, maximum value, range, and skewness and kurtosis statistics. As shown in the output, mean number of years for duration is 1.89, and the SD is 1.22. The 95% CI is 1.02–2.76. Explore 301Calculating Descriptive Statistics • EXERCISE 27Copyright © 2017, Elsevier Inc. All rights reserved. STUDY QUESTIONS 1. Defi ne mean. 2. What does this symbol, s 2 , represent? 3. Defi ne outlier. 4. Are there any outliers among the values representing duration of biologic use? 5. How would you interpret the 95% confi dence interval for the mean of duration of biologic use? 6. What percentage of patients were Black, not of Hispanic origin? 7. Can you compute the variance for duration of biologic use by using the information presented in the SPSS output above?

 

 

 

 

Copyright © 2017, Elsevier Inc. All rights reserved. 305 Questions to Be Graded

 

EXERCISE 27 Follow your instructor ’ s directions to submit your answers to the following questions for grading. Your instructor may ask you to write your answers below and submit them as a hard copy for grading. Alternatively, your instructor may ask you to use the space below for notes and submit your answers online at http://evolve.elsevier.com/Grove/statistics/ under “

 

 

Name: _______________________________________________________

Class: _____________________

Date:_____________________

 

 

 

Questions to Be Graded.”

 

1. What is the mean age of the sample data?

 

2. What percentage of patients never used tobacco?

 

3. What is the standard deviation for age?

 

4. Are there outliers among the values of age? Provide a rationale for your answer.

 

5. What is the range of age values?

 

6. What percentage of patients were taking infl iximab?

 

7. What percentage of patients had rheumatoid arthritis as their primary diagnosis?

 

8. What percentage of patients had irritable bowel syndrome as their primary diagnosis?

 

9. What is the 95% CI for age?

 

10. What percentage of patients had psoriatic arthritis as their primary diagnosis?

 

 

 

 

 

 

 

Copyright © 2017, Elsevier Inc. All rights reserved. 307 Calculating Pearson Product-Moment Correlation Coeffi cient Correlational analyses identify associations between two variables. There are many differ-ent kinds of statistics that yield a measure of correlation. All of these statistics address a research question or hypothesis that involves an association or relationship. Examples of research questions that are answered with correlation statistics are, “Is there an associa-tion between weight loss and depression?” and “Is there a relationship between patient satisfaction and health status?” A hypothesis is developed to identify the nature (positive or negative) of the relationship between the variables being studied. The Pearson product-moment correlation was the fi rst of the correlation measures developed and is the most commonly used. As is explained in Exercise 13 , this coeffi cient (statistic) is represented by the letter r , and the value of r is always between − 1.00 and + 1.00. A value of zero indicates no relationship between the two variables. A positive cor-relation indicates that higher values of x are associated with higher values of y . A negative or inverse correlation indicates that higher values of x are associated with lower values of y . The r value is indicative of the slope of the line (called a regression line) that can be drawn through a standard scatterplot of the two variables (see Exercise 11 ). The strengths of different relationships are identifi ed in Table 28-1 ( Cohen, 1988 ). EXERCISE 28 TABLE 28-1 STRENGTH OF ASSOCIATION FOR PEARSON r Strength of Association Positive Association Negative Association Weak association0.00 to < 0.300.00 to < − 0.30Moderate association0.30 to 0.49 − 0.49 to − 0.30Strong association0.50 or greater − 1.00 to − 0.50 RESEARCH DESIGNS APPROPRIATE FOR THE PEARSON r Research designs that may utilize the Pearson r include any associational design ( Gliner, Morgan, & Leech, 2009 ). The variables involved in the design are attributional, meaning the variables are characteristics of the participant, such as health status, blood pressure, gender, diagnosis, or ethnicity. Regardless of the nature of variables, the variables submit-ted to a Pearson correlation must be measured as continuous or at the interval or ratio level. STATISTICAL FORMULA AND ASSUMPTIONS Use of the Pearson correlation involves the following assumptions: 1. Interval or ratio measurement of both variables (e.g., age, income, blood pressure, cholesterol levels). However, if the variables are mea